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BOC Sciences |
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Product Name:(3alpha,5beta,6beta,7alpha)-6-Ethylcholane-3,7,24-triol
CAS:1632118-70-7
Package:10mg Remarks:BOC Sciences also provides custom synthesis services for (3alpha,5beta,6beta,7alpha)-6-Ethylcholane-3,7,24-triol.
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| | BAR 501 impurity Basic information |
| Product Name: | BAR 501 impurity | | Synonyms: | BAR 501 impurity;(3R,5S,6S,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-17-[(2R)-5-hydroxypentan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol;(3alpha,5beta,6beta,7alpha)-6-Ethylcholane-3,7,24-triol;Cholane-3,7,24-triol, 6-ethyl-, (3α,5β,6β,7α)- | | CAS: | 1632118-70-7 | | MF: | C26H46O3 | | MW: | 406.64 | | EINECS: | | | Product Categories: | | | Mol File: | 1632118-70-7.mol |  |
| | BAR 501 impurity Chemical Properties |
| Boiling point | 527.6±25.0 °C(Predicted) | | density | 1.047±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 20 mg/mL; DMSO: 100μg/ml; Ethanol: 2 mg/mL; Ethanol:PBS (pH 7.2)(1:2): 500μg/ml | | form | A crystalline solid | | pka | 14.82±0.70(Predicted) |
| | BAR 501 impurity Usage And Synthesis |
| Description | BAR501 impurity is an impurity found in the preparation of BAR501 that acts as an agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1). BAR501 impurity (10 μM) induces a 150% increase in luciferase activity in a GP-BAR1 reporter gene assay.1 | | References | 1. Festa, C., Renga, B., D'Amore, C., et al. Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands J. Med. Chem. 57(20),8477-8495(2014). |
| | BAR 501 impurity Preparation Products And Raw materials |
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