Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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Tel: |
400-9205774 |
Email: |
sales@glpbio.cn |
Products Intro: |
Product Name:L-902,688 CAS:634193-54-7 Purity:>98% Package:1mg;10mg;50mg;100mg;
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Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Tel: |
18818260767 |
Email: |
sales@chemegen.com |
Products Intro: |
Product Name:L-902,688 CAS:634193-54-7 Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Company Name: |
MedBioPharmaceutical Technology Inc
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Tel: |
021-69568360 18916172912 |
Email: |
order@med-bio.cn |
Products Intro: |
Product Name:L-902,688 CAS:634193-54-7 Purity:98% Package:1mg (solution); 500ug (solution); 5mg (solution); 10mg (solution) Remarks:Medbio
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| L-902,688 Basic information |
Product Name: | L-902,688 | Synonyms: | L-902,688;L-902,688 Exclusive;(5R)-5-[(E,3R)-4,4-difluoro-3-hydroxy-4-phenylbut-1-enyl]-1-[6-(2H-tetrazol-5-yl)hexyl]pyrrolidin-2-one;2-Pyrrolidinone, 5-[(1E,3R)-4,4-difluoro-3-hydroxy-4-phenyl-1-buten-1-yl]-1-[6-(2H-tetrazol-5-yl)hexyl]-, (5R)-;L902688,L 902688 | CAS: | 634193-54-7 | MF: | C21H27F2N5O2 | MW: | 419.468 | EINECS: | | Product Categories: | | Mol File: | 634193-54-7.mol | |
| L-902,688 Chemical Properties |
storage temp. | Store at -20°C | solubility | DMF:30.0(Max Conc. mg/mL);71.52(Max Conc. mM) DMSO:30.0(Max Conc. mg/mL);71.52(Max Conc. mM) Ethanol:30.0(Max Conc. mg/mL);71.52(Max Conc. mM) Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.19(Max Conc. mM) |
| L-902,688 Usage And Synthesis |
Description | Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. L-902,688 is a highly potent agonist of the human PGE2 receptor, EP4. It demonstrates a Ki value of 0.38 nM and an EC50 value of 0.6 nM and is >4,000-fold selective for EP4 over other EP and prostanoid receptors. L-902,688 induces thermal hyperalgesia when injected into guinea pig forepaw and increases vasodilation of human pulmonary vein. |
| L-902,688 Preparation Products And Raw materials |
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