| Company Name: |
kemikalieimport
|
| Tel: |
+ 45 - 2034 3359 |
| Email: |
Sales@kemikalieimport.dk |
| Products Intro: |
|
|
| | Homofenazine Basic information |
| Product Name: | Homofenazine | | Synonyms: | Homofenazine | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Homofenazine Structure]() |
| | Homofenazine Chemical Properties |
| | Homofenazine Usage And Synthesis |
| Originator | Pasaden,Homburg,Italy,1972 | | Manufacturing Process | 35 parts of 3-trifluoromethyl-phenothiazine in 200 parts of toluene were
reacted with 6.1 parts soda amide and then with 28.8 parts of 3-bromopropylhomopiperazine. After a 2 hour reaction period the reaction mixture was
washed with water twice and then extracted with dilute HCl, the resulting
extract alkalized with excess K2CO3 and the precipitated base taken up in
ether. After drying the ether extract and evaporation of the ether, the residue
was distilled. 20.3 parts of 3-trifluoromethyl-10-(3'-homopiperazino)-propylphenothiazine having a boiling point of 225° to 230°C at 1 mm Hg pressure
were obtained.
20 parts of 3-trifluoromethyl-10-(3'-homopiperazino)-propyl-phenothiazine in
100 parts of butanol were refluxed for 4 hours together with 5.5 parts of 2-
chloroethanol and 11 parts potassium carbonate. The reaction mixture was
diluted with 200 parts of ether, then washed three times with water and dried
with potassium carbonate. After evaporation of the solvent the residue was
distilled under a vacuum of 1 mm Hg. 17.5 parts of 3-trifluoro methyl-10-[3'-
(4"-(2"-hydroxyethyl)-homopiperazino)-propyl]-phenothiazine distilled over at
230° to 240°C. The difumarate of this base had a melting point of 148°C. | | Therapeutic Function | Tranquilizer |
| | Homofenazine Preparation Products And Raw materials |
|