| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Leukemia Inhibitory Factor
Purity:>=95% (SDS-PAGE) Package:10μg Remarks:L5283
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| Company Name: |
Wuhan Chemstan Biotechnology Co., Ltd.
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| Tel: |
027-65317797 15926423062 |
| Email: |
422450190@qq.com |
| Products Intro: |
Product Name:Recombinant Human LIF/Leukemia inhibitory factor Protein, No Tag
Purity:90% as determined by SDS-PAGE Package:50ug;100ug
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| | LEUKEMIA INHIBITORY FACTOR, MOUSE Basic information |
| Product Name: | LEUKEMIA INHIBITORY FACTOR, MOUSE | | Synonyms: | Leukemia Inhibitory Factor from mouse;MOUSE LIF;ESGRO;LEUKEMIA INHIBITORY FACTOR;LEUKEMIA INHIBITORY FACTOR, MOUSE;LEUKEMIA INHIBITORY FACTOR MURINE;LIF;LIF, MOUSE | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![LEUKEMIA INHIBITORY FACTOR, MOUSE Structure]() |
| | LEUKEMIA INHIBITORY FACTOR, MOUSE Chemical Properties |
| storage temp. | 2-8°C | | form | buffered aqueous solution |
| | LEUKEMIA INHIBITORY FACTOR, MOUSE Usage And Synthesis |
| Uses | Leukemia Inhibitory Factor from mouse has been used:
- as a component of enriched co-culture media
- as a supplement in Dulbecco′s modified eagle′s medium (DMEM)/F12 medium for culturing heart cells
- as a component in maintenance medium for maintaining embryonic stem cells
- to treat ovaries in ovarian culture
| | Biochem/physiol Actions | Leukemia Inhibitory Factor (LIF) is a pleiotropic glycoprotein originally described to inhibit the proliferation of the murine myeloid leukemic cell line M1, while inducing differentiation into macrophages. Other activities were later identified to LIF, which is known by a variety of synonyms, including DIF, D-factor, DIA, DRF, CNDF, HILDA, HSF-III, and MLPLI. Human LIF exerts its actions through a receptor comprising a 190 kDa LIF-binding α-chain (130 kDa, mouse) and a 130 kDa signal-transducing β-chain (gp130), which is shared with CNTF, OSM, L-6 and IL-11. As such, it is a member of the gp130 family of the cytokine receptor superfamily. LIF receptors have been identified on several cells, including monocytes, liver, placenta and embryonic stem cells. Natural LIF is heavily glycosylated, showing an apparent molecular weight of 32 kDa to 62 kDa, depending on the source, but absence of glycosylation appears not to affect its biological activity. A single gene encodes LIF, which is secreted as a single chain glycoprotein containing 180 amino acids for human or mouse with a conserved disulfide bond. Human and mouse LIF share 78% sequence homology. Human LIF can activate mouse cells, but mouse LIF cannot activate human cells. |
| | LEUKEMIA INHIBITORY FACTOR, MOUSE Preparation Products And Raw materials |
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