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2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride

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Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:ABT-724 trihydrochloride
CAS:587870-77-7
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: BOC Sciences
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Products Intro: Product Name:ABT 724 trihydrochloride
CAS:587870-77-7
Purity:>=99% by HPLC Package:100mg Remarks:BOC Sciences also provides custom synthesis services for ABT 724 trihydrochloride.
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Products Intro: Product Name:ABT 724 trihydrochloride
CAS:587870-77-7
Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；2 mg；200 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Alfa Chemistry
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Products Intro: Product Name:ABT-724 trihydrochloride
CAS:587870-77-7
Purity:96% Remarks:https://www.alfa-chemistry.com/cas_587870-77-7.htm
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Products Intro: Product Name:ABT-724 trihydrochloride
CAS:587870-77-7
Purity:98% Package:10mg Remarks:V40042
2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride Basic information
Product Name:2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride
Synonyms:2-((4-(Pyridin-2-yl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole trihydrochloride;ABT-724 (hydrochloride);Inhibitor,Dopamine Receptor,penile,inhibit,potentiation,side-effect,ABT-724 trihydrochloride,Dopamine,D4-receptor,ABT 724 trihydrochloride,erection
CAS:587870-77-7
MF:C17H22Cl3N5
MW:402.74908
EINECS:
Product Categories:
Mol File:587870-77-7.mol
2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride Structure
2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride Chemical Properties
storage temp. 2-8°C
solubility H2O: >30mg/mL
form powder
color white
Water Solubility Soluble to 100 mM in water
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
WGK Germany 3
MSDS Information
2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride Usage And Synthesis
DescriptionABT-724 is a dopamine D4 receptor agonist with an EC50 value of 12.4 nM in a FLIPR calcium flux assay using HEK293 cells expressing the human D4.4 receptor and Gαqo5. It is selective for dopamine D4 over D2 receptors at 10 μM. ABT-724 (0.03 μmol/kg) induces penile erections in 77% of male rats. It decreases mounting frequency and ejaculation latency and increases ejaculation frequency and copulatory efficacy in male rats when administered at a dose of 0.04 mg/kg. ABT-724 (0.16 and 0.64 mg/kg) decreases hyperactivity and exploratory behavior in the open field test in an adolescent spontaneously hypertensive rat (SHR) model of attention-deficit hyperactivity disorder (ADHD).
storage+4°C (desiccate)
references[1]. sarkar c, das s, chakroborty d, et al. cutting edge: stimulation of dopamine d4 receptors induce t cell quiescence by up-regulating kruppel-like factor-2 expression through inhibition of erk1/erk2 phosphorylation. j immunol, 2006, 177(11):7525-9.
[2]. melis mr, succu s, mascia ms, et al. pd-168077, a selective dopamine d4 receptor agonist, induces penile erection when injected into the paraventricular nucleus of male rats. neurosci lett, 2005, 379(1):59-62.
[3]. sanna f, contini a, melis mr, et al. role of dopamine d4 receptors in copulatory behavior: studies with selective d4 agonists and antagonists in male rats. pharmacol biochem behav, 2015, 137:110-8.
[4]. arranz m, collier d, sodhi m, et al. association between clozapine response and allelic variation in 5-ht2a receptor gene. lancet, 1995, 346(8970):281-2.
[5]. boehmler w, carr t, thisse c, et al. d4 dopamine receptor genes of zebrafish and effects of the antipsychotic clozapine on larval swimming behaviour. genes brain behav, 2007, 6(2):155-66.
2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride Preparation Products And Raw materials
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