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Postion:Product Catalog >Analytical Chemistry>Standard>Spectral Standards> Isatin
Isatin
  • Isatin
  • Isatin

Isatin NEW

Price $6 $5 $0.8
Package 1kg 25kg 100kg
Min. Order: 1kg
Supply Ability: g-kg-tons, free sample is available
Update Time: 2024-03-29

Product Details

Product Name: Isatin CAS No.: 91-56-5
Min. Order: 1kg Purity: 99%
Supply Ability: g-kg-tons, free sample is available Release date: 2024/03/29
Lead time: In stock Packaging: bottle/drum/bucket/IBC, as request.
Delivery: By sea, by air, by express Origin: Manufacturer
Name: Sun

1. Product information

Names

Nameisatin
SynonymMore Synonyms

 isatin Biological Activity

DescriptionIsatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM)[1]. Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity[2]. Shows effect on the serotonergic system[3].
Related Catalog
Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase
Natural Products >> Alkaloid
Research Areas >> Cancer
Research Areas >> Cardiovascular Disease
Research Areas >> Neurological Disease
Target

IC50: 3 μM (MAO B)[1]

In VitroIn dopaminergic SH-SY5Y cells isatin (1-400 μM) induces cell death in dose- and time dependent manner. This death occurred as a continuum of survival, apoptosis and necrosis[2].
In VivoA single dose of isatin (80 mg/kg) has a rapid effect on the serotonergic system in the hypothalamus. Isatin significantly increases 5-HT concentrations in the hypothalamus and cortex but did not significantly alter 5-HIAA concentrations[3].
References

[1]. Glover V, et al. Isatin: Identity with the Purified Endogenous Monoamine Oxidase Inhibitor Tribulin. Journal of Neurochemistry, 51(2), 656–659.

[2]. Igosheva N, et al. Isatin, an endogenous monoamine oxidase inhibitor, triggers a dose- and time-dependent switch from apoptosis to necrosis in human neuroblastoma cells. Neurochem Int. 2005 Aug;47(3):216-24.

[3]. McIntyre IM, et al. Serotonergic effects of isatin: an endogenous MAO inhibitor related to tribulin. J Neural Transm Gen Sect. 1990;79(1-2):35-40.

 Chemical & Physical Properties

Density1.4±0.1 g/cm3
Boiling Point360.3±52.0 °C at 760 mmHg
Melting Point193-195 °C (dec.)(lit.)
Molecular FormulaC8H5NO2
Molecular Weight147.131
Flash Point171.7±30.7 °C
Exact Mass147.032028
PSA46.17000
LogP-0.17
Vapour Pressure0.0±1.8 mmHg at 25°C
Index of Refraction1.679
Storage conditionStore at RT.

 MSDS

isatin MSDS(Chinese)

 Toxicological Information

CHEMICAL IDENTIFICATION

  • RTECS NUMBER :

  • NL7873000

  • CHEMICAL NAME :

  • Indole-2,3-dione

  • CAS REGISTRY NUMBER :

  • 91-56-5

  • BEILSTEIN REFERENCE NO. :

  • 0383659

  • LAST UPDATED :

  • 199701

  • DATA ITEMS CITED :

  • 9

  • MOLECULAR FORMULA :

  • C8-H5-N-O2

  • MOLECULAR WEIGHT :

  • 147.14

  • WISWESSER LINE NOTATION :

  • T56 BMVVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

  • TYPE OF TEST :

  • LDLo - Lowest published lethal dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 5 gm/kg

  • TOXIC EFFECTS :

  • Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - changes in motor activity (specific assay)

  • REFERENCE :

  • IJPPAZ Indian Journal of Physiology and Pharmacology. (All India Institute of Medical Sciences, Dept. of Physiology, Ansari Nagar, New Delhi 110 029, India) V.1- 1957- Volume(issue)/page/year: 6,145,1962

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 7740 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 27(8),54,1983

  • TYPE OF TEST :

  • LD - Lethal dose

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • >800 mg/kg

  • TOXIC EFFECTS :

  • Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - changes in motor activity (specific assay)

  • REFERENCE :

  • IJPPAZ Indian Journal of Physiology and Pharmacology. (All India Institute of Medical Sciences, Dept. of Physiology, Ansari Nagar, New Delhi 110 029, India) V.1- 1957- Volume(issue)/page/year: 6,145,1962

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Unreported

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 725 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - somnolence (general depressed activity)

  • REFERENCE :

  • RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 41,146,1978

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 330 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 55,1514,1959 ** OTHER MULTIPLE DOSE TOXICITY DATA **

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 43500 mg/kg/6W-I

  • TOXIC EFFECTS :

  • Blood - pigmented or nucleated red blood cells Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in erythrocyte (RBC) count

  • REFERENCE :

  • GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 27(3),52,1983 ** REPRODUCTIVE DATA **

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 200 mg/kg

  • SEX/DURATION :

  • male 1 day(s) pre-mating

  • TOXIC EFFECTS :

  • Reproductive - Paternal Effects - other effects on male

  • REFERENCE :

  • IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Volume(issue)/page/year: 67,73,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1765 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 198 (estimated) No. of Female Employees: 151 (estimated)

 Safety Information

Personal Protective Equipmentdust mask type N95 (US);Eyeshields;Gloves
Hazard CodesXi,Xn
Risk PhrasesR36/37/38
Safety PhrasesS26-S36-S24/25
RIDADR2811
WGK Germany1
RTECSNL7873000
Packaging GroupIII
Hazard Class6.1(b)
HS Code2933990090

 Synthetic Route

Previous 1/54 Next
Article illustration

Chloral hydrate

302-17-0

Article illustration


74497-02-2

~64%

Article illustration

isatin

91-56-5

Literature: Liu, Hua-Quan; Wang, De-Cai; Wu, Fei; Tang, Wei; Ouyang, Ping-Kai Chinese Chemical Letters, 2013 , vol. 24, # 10 p. 929 - 933
Article illustration

Indole

120-72-9

~8%

Article illustration

Oxindole

59-48-3

Article illustration

isatin

91-56-5

Literature: Applied Catalysis A: General, , vol. 470, p. 427 - 433
Article illustration

Indole

120-72-9

~6%

Article illustration

Oxindole

59-48-3

Article illustration

Indirubin

479-41-4

Article illustration

isatin

91-56-5

Literature: Applied Catalysis A: General, , vol. 470, p. 427 - 433

 Precursor & DownStream

Precursor  9

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  • Article illustration CAS#:302-17-0
    Chloral hydrate

  • Article illustration CAS#:120-72-9
    Indole

  • Article illustration CAS#:487-89-8
    Indole-3-carbox...

  • Article illustration CAS#:201230-82-2
    carbon monoxide

DownStream  10

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    3-(1,3-thiazol-...

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 Customs

HS Code2933990090
Summary2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles78

More Articles
Unprecedented one-pot, domino tertiary alcohol protection-Michael type addition of halides to Morita-Baylis-Hillman adduct of isatin with RCOX/K2CO3: diastereoselective synthesis of oxindole appended β-halo esters.

Org. Lett. 15(6) , 1186-9, (2013)

A facile method utilizing RCOX/K2CO3 as a novel reagent for conjugate addition of hydrogen halide, in addition to tertiary (3°)-hydroxyl protection that leads to the synthesis of functionalized β-halo...

Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.

J. Med. Chem. 54 , 5320, (2011)

Tryptophan catabolism mediated by indoleamine 2,3-dioxygenase (IDO) is an important mechanism of peripheral immune tolerance contributing to tumoral immune resistance. IDO inhibition is thus an active...

Reactivity of dinuclear copper(II) complexes towards melanoma cells: Correlation with its stability, tyrosinase mimicking and nuclease activity.

J. Inorg. Biochem. 149 , 49-58, (2015)

In this work, the influence of two new dinuclear copper(II) complexes in the viability of melanoma cells (B16F10 and TM1MNG3) was investigated, with the aim of verifying possible correlations between ...

 Synonyms

Indolequinone
EINECS 202-077-8
MFCD00005718
indole-2,3-dione
indoline-2,3-dione
Indoquinone
2,3-Dioxoindoline
2,3-Dioxo-2,3-dihydroindole
2,3-Indolinedione
2,3-INDOLEDIONE
2H-Indol-2-one, 3-hydroxy-
3-hydroxy-2-oxoindole
ISATIC ANHYDRIDE
Isotin
2,3-Diketoindoline
2-methopropan-1-ol
3-Hydroxy-2H-indol-2-one
Isatin
2,3-KETOINDOLINE
5-21-10-00221 (Beilstein Handbook Reference)
2,3-dihydro-1H-indol-2,3-dione



2. Packaging

For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product. 

                     Or smaller package 1kg/bottle, 10kgs/bottle as request. 


Article illustrationArticle illustration


3. Shipping

Article illustration


4. Contact information

For more details, pls contact us freely.

Email address : Sun@fdachem.com

Mob: 86 13526505137

WhatsApp/Skype/Wechat/LINE: 86 13526505137








Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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Henan Fengda Chemical Co., Ltd

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  • Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro
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