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Postion:Product Catalog >API>Antibiotics>Other antibiotic Drugs>trichostatin A
trichostatin A
  • trichostatin A
  • trichostatin A
  • trichostatin A
  • trichostatin A
  • trichostatin A

trichostatin A

Price Get Latest Price
Package 1KG
Min. Order: 1g
Supply Ability: 1 ton
Update Time: 2021-03-17

Product Details

Product Name: trichostatin A CAS No.: 58880-19-6
Min. Order: 1g Purity: 99.9%
Supply Ability: 1 ton Release date: 2021/03/17

简介

曲古抑菌素A(TSA)是一种有机化合物,用作抗真菌抗生素,并选择性地抑制I类和II类哺乳动物组蛋白脱乙酰酶(HDAC)家族的酶,而不是III类HDAC(即sirtuins)。TSA在生长阶段开始时抑制真核细胞周期。TSA可用于通过干扰去除组蛋白(组蛋白脱乙酰酶,HDAC)的乙酰基来改变基因表达,从而改变DNA转录因子进入染色质内的DNA分子的能力。它是具有广谱表观遗传活性的更大类组蛋白脱乙酰酶抑制剂(HDIs或HDACI)的成员。因此,TSA具有作为抗癌药物的一些潜力。一个建议的机理是TSA促进凋亡相关基因的表达,导致癌细胞以较低的速率存活,从而减缓癌症的进展。其他机制可能包括HDIs诱导细胞分化的活性,从而起到“成熟”肿瘤中发现的一些去分化细胞的作用。 HDI对非组蛋白效应分子具有多重作用,因此目前尚无法了解抗癌机制。

基本信息

中文名称
曲古柳菌素A
英文名称
trichostatin A
中文别名

曲古抑菌素A; 曲古抑菌素;

英文别名

(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide; TRICHOSTATIN A;

CAS号
58880-19-6
分子式
C17H22N2O3
分子量
302.36800
精确质量
302.16300
PSA
69.64000
LOGP
2.97020

物化性质

外观与性状:
灰白色粉末
密度:
1.139 g/cm3
熔点:
141-143ºC
储存条件:
-20ºC

安全信息

安全说明:
S26; S36
危险类别码:
R20/21/22
海关编码:
2924299090
危险品标志:
Xn 

简介

曲古抑菌素A(TSA)是一种有机化合物,用作抗真菌抗生素,并选择性地抑制I类和II类哺乳动物组蛋白脱乙酰酶(HDAC)家族的酶,而不是III类HDAC(即sirtuins)。TSA在生长阶段开始时抑制真核细胞周期。TSA可用于通过干扰去除组蛋白(组蛋白脱乙酰酶,HDAC)的乙酰基来改变基因表达,从而改变DNA转录因子进入染色质内的DNA分子的能力。它是具有广谱表观遗传活性的更大类组蛋白脱乙酰酶抑制剂(HDIs或HDACI)的成员。因此,TSA具有作为抗癌药物的一些潜力。一个建议的机理是TSA促进凋亡相关基因的表达,导致癌细胞以较低的速率存活,从而减缓癌症的进展。其他机制可能包括HDIs诱导细胞分化的活性,从而起到“成熟”肿瘤中发现的一些去分化细胞的作用。 HDI对非组蛋白效应分子具有多重作用,因此目前尚无法了解抗癌机制。

基本信息

中文名称
曲古柳菌素A
英文名称
trichostatin A
中文别名

曲古抑菌素A; 曲古抑菌素;

英文别名

(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide; TRICHOSTATIN A;

CAS号
58880-19-6
分子式
C17H22N2O3
分子量
302.36800
精确质量
302.16300
PSA
69.64000
LOGP
2.97020

物化性质

外观与性状:
灰白色粉末
密度:
1.139 g/cm3
熔点:
141-143ºC
储存条件:
-20ºC

安全信息

安全说明:
S26; S36
危险类别码:
R20/21/22
海关编码:
2924299090
危险品标志:
Xn

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Company Profile Introduction

Welcome to hebei Shuoxi biotechnology co., LTD. Shuoxi is a fast developing pharmaceutical intermediates enterprise located in shijiazhuang, capital of hebei province. Shuoxi analysis research and development center also provides custom synthesis service. Hebei Shuoxi biotechnology co., LTD can provide customized synthetic chemicals in different quantities in laboratories, factories and industrial scale. We have more than 10 years experience in this field. We can offer competitive price for every customer and guarantee the quality of our products. 3. We pay attention to the needs of each customer and build a good relationship with them. 4. We have long-term business relations with Canada, Mexico, Brazil, UK, Russia, Germany, USA, India, South Africa, Malta, Egypt, Armenia, Australia, Philippines, Belgium, Netherlands, Denmark and other countries. If you have any other questions for me. Please feel free to contact me. We only produce and sell products that are legal in China. All products are sold only to laboratory research.

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