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Postion:Product Catalog >API>Respiratory Drugs>Antitussives>DEXTROMETHORPHAN
DEXTROMETHORPHAN
  • DEXTROMETHORPHAN

DEXTROMETHORPHAN

Price $9.9
Package 1g
Min. Order: 1g
Supply Ability: 1000g
Update Time: 2024-06-09

Product Details

Product Name: DEXTROMETHORPHAN CAS No.: 125-71-3
Min. Order: 1g Purity: 99%
Supply Ability: 1000g Release date: 2024/06/09

Product number: Flora1  

Company Service Scope:

1. Samples synthetic, Our strong r&d team has accumulated abundant experience in synthesis design and exploring synthesis of new technology. Not only good at heterocyclic chemistry, chiral chemicals (asymmetric synthesis and enzyme reaction), metal organic synthesis, high throughput chemistry, also specializes in bioorganic chemistry including nucleosides, nucleotides, sugar chemical, peptide chemistry, etc, to complete the synthesis from mg to kg samples in lab scale. Our efficient management and good communication skills and ability to solve the problem rapidly in order to ensure quality, timely delivery, based on the standard client confidential system and competitive price products,we has been recognized and praised by many customers in chemical industry.

2. Scale-up production, based on our rich laboratory experience and advanced equipment in production base, also depend on accumulation of advantages in many aspects as industrialized technology development, the production cost control, to provide from kg class to wt class custom synthesis scale-up production services to the global fine chemical industry, can be carried out oxidation, hydrogenation pressure (70 kg), halide, and acylation, esterification, condensation, cyclization, formatting, ammoniation, diazotization and azide reaction, our experienced production management, strict and perfect management system can quickly provide customers with competitive and fine mass production services.

3.Technology transfer, the company has accumulated a large number of production processes of drugs, intermediates and raw material. Based on the principle of mutual benefit, and some technology transfer to industry manufacturers, also provides them marketing support.

4. Purchasing agency service, Our excellence professional sales team, timely and thoughtful service, in addition to the necessary good language communication ability of professional sales staff, also equipped with professional chemical technical sales consultant, who can answer the customer's academic professional question, we are in line with the aim of offering customer wholehearted service, with our advanced testing equipment checks and abundant R&D and production of domestic partner contacts, to provide rare chemicals with standard purity, reasonable price and cost-effective purchasing agency service to foreign customers, and the help you shorten the sourcing time, reduce the purchasing cost.

DEXTROMETHORPHAN Basic information
Product Name:DEXTROMETHORPHAN
Synonyms:Dextromethorphan (CRM);D-methorphan;Methorphan;Morphinan, 3-methoxy-17-methyl-, (9alpha,13alpha,14alpha)-;Racemethorphan [as d-form];(+)-3-methoxy-N-methylmorphinan;(+)-cis-1,3,4,9,10,10a-hexahydro-6-methoxy-11-methyl-2H-10,4a-iminoethanophenanthrene;Benylin DM
CAS:125-71-3
MF:C18H25NO
MW:271.4
EINECS:204-752-2
Product Categories:-
Mol File:125-71-3.mol
Article illustration

DEXTROMETHORPHAN Chemical Properties
Boiling point 414.48°C (rough estimate)
density 1.0115 (rough estimate)
refractive index 1.5740 (estimate)
Fp 9℃
storage temp. ?20°C
pkapKa 8.3 (Uncertain)
InChIKeyMKXZASYAUGDDCJ-CGTJXYLNSA-N
CAS DataBase Reference125-71-3(CAS DataBase Reference)

Safety Information
Hazard Codes F,T
Risk Statements 11-23/24/25-39/23/24/25
Safety Statements 16-36/37-45
RIDADR 3249
WGK Germany 1
RTECS QD0194000
HazardClass 6.1(b)
PackingGroup III

MSDS Information
 

DEXTROMETHORPHAN Usage And Synthesis
UsesAntitussive.
DefinitionChEBI: An organic heterotetracyclic compound that is morphinan substituted by a methoxy group at position 3 and a methyl group at position 7. It is used as an antitussive drug for suppressing cough.
Brand nameBenylin DM (Parke-Davis); Dextromethorphan Hydrobromide OROS Tablets (Ciba-Geigy); Drixoral Cough (Schering-Plough HealthCare); PediaCare 1 (McNeil Consumer); Romilar (Hoffmann-LaRoche-International); St. Joseph Cough Syrup (Schering-Plough HealthCare);Agrippol;Dextophan;Dextrophen.
Biological FunctionsDextromethorphan hydrobromide is the D-isomer of levorphanol. It lacks CNS activity but acts at the cough center in the medulla to produce an antitussive effect. It is half as potent as codeine as an antitussive. Anecdotal reports of abuse exist, but studies of abuse potential are lacking. It has few side effects but does potentiate the activity of monoamine oxidase inhibitors, leading to hypotension and infrequently coma. Dextromethorphan is often combined in lozenges with the local anesthetic benzocaine, which blocks pain from throat irritation due to coughing.
General DescriptionDextromethorphan is the dextrorotatory form of levorphanolwith a methoxy group on the 3-position. It is availablein more than 140 over-the-counter (OTC) cough and coldformulations. Evidence-based reviews have been unable toconclude that it is more effective than placebo in reducingcough. Like (+) and (-) levorphanol, (+) dextromethorphanis a potent NMDA antagonist and, in higher than recommendeddoses, has the potential for causing dissociativeanesthetic effects similar to ketamine or phencyclidine (PCP).The OTC status and availability of pure dextromethorphanpowder online has contributed greatly to its abuse in recentyears. DAWN reports that in 2004, there were approximately12,500 emergency room visits involving dextromethorphanwith 44% of those involving abuse of the drug. The 2006National Survey on Drug Abuse report shows that nearly 1million persons aged 12 to 25 years (1.7%) misused OTCcough and cold medications in the past year.
Dextromethorphan’s ability to antagonize the NMDA receptorhas led to its use to treat phantom pain, diabetic neuropathy,and postoperative acute pain.
 


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  • Since: 2023-03-16
  • Address: Room 21, Floor 7, Building 3, SBI Chuangye Street, Dongxin Road, Donghu New Technology Development Z
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