Welcome to chemicalbook!
+1 (818) 612-2111
Inquriy
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >API>Antineoplastic agents>Hormonal antineoplastic drugs>Letrozole
Letrozole
  • Letrozole
  • Letrozole
  • Letrozole
  • Letrozole
  • Letrozole

Letrozole

Price Get Latest Price
Package 25Kg/Bag
Min. Order: 2Kg/Bag
Supply Ability: 20 tons
Update Time: 2024-06-04

Product Details

Product Name: Letrozole CAS No.: 112809-51-5
Min. Order: 2Kg/Bag Purity: 99% up, High Density
Supply Ability: 20 tons Release date: 2024/06/04

Product Information

Product name

Letrozole

Molecular Formula

C17H11N5

Molecular Weight

285.3

CAS No.

112809-51-5

Quality Standard

USP32, medical grade

Appearance

White powder

COA of Letrozole

Items

Specification

Appearance

White to yellowish, crystalline powder

Identification

A.IR spectrum of sample should be identical to that of Reference Standard;

The retention time of major peak in the chromatogram of the Assay preparation should correspond to that in the chromatogram of Standard preparation, as obtained in the Assay.

Showing the white precipitate reaction.

Water

Not more than 0.3%

Residue on Ignition

Not more than 0.1%

Heavy Metals

Not more than 0.001%

 

Related Compounds

Compound A: Not more than 0.1%

4,4’,4”-methylidenetrisbenzonitrile: Not more than 0.2%

Any other impurity: Not more than 0.1%

All other impurities: Not more than 0.3%

Residual Sovents

Ethanol: Not more than 3000ppm

Ethyl acetate: Not more than 2000ppm

DMF: Not more than 880ppm

Microbe Limit

Bacteria: Not more than 200/g

Mold and yeast: Not more than 50/g

Escherichia coli: should be absent

Assay(anhydrous)

98.0% to 102.0% of Cl7H11N5 on dried basis

Packaging and Storage

Preserve in tight containers at controlled room temperature.

Conclusion

Conforms to the USP32.

Usage

Function of Letrozole
Letrozole is a new generation of highly selective aromatase inhibitors. It is a synthetic benztriazole derivative. By inhibiting aromatase, estrogen levels are reduced, thereby eliminating the stimulating effect of estrogen on tumor growth. The activity in the body is 150-250 times stronger than that of the first generation aromatase inhibitor amuromet. Because of its high selectivity, it does not affect glucocorticoids, mineralocorticoids, and thyroid function. Large doses have no inhibitory effect on the secretion of adrenal corticosteroids, so it has a high therapeutic index. Various preclinical studies have shown that letrozole has no potential toxicity, mutagenicity and carcinogenic effects on various systems and target organs in the whole body, and has less toxic and side effects, and is well tolerated. Compared with estrogen drugs, the anti-tumor effect is stronger. It is suitable for the treatment of postmenopausal patients with advanced breast cancer who are not responding to anti-estrogen therapy and early treatment of breast cancer.


In December 2005, the British drug and health product regulatory agency approved Letrozole (Fron) produced by Novartis of Switzerland to be used in the treatment of breast cancer patients, allowing it to be used in surgically treated, early menopausal hormone-positive mammary glands Cancer patients. This is the second aromatase inhibitor approved following the approval of AstraZeneca ’s Rainin in June 2005. Both drugs have shown in clinical trials that they can better prevent the risk of breast cancer recurrence compared to current standard tamoxifen treatment.

Article illustration

Company Profile Introduction

Sinoway Industrial co., ltd. was established in 1987 in Xiamen, China, and now has been a leading group specialized in research, development, custom manufacturing and trading of pharmaceutical intermediates, APIs, health and food supplements, cosmetic raw materials, herbal extracts, polypeptides and prostaglandin derivatives, etc.. We have passed ISO9001:2015. With qualified products, competitive price and excellent service, we have received great reputation of our customers from all over the world, including Southeast Asia, Europe, North America, South America, Middle East and other countries. We have over 20 years good partners in Japan、Korea and Switzerland. Sinoway has a professional R&D team. We have built close cooperative relationships with many research institutes and universities in China. Moreover, Sinoway combines market analysis with technology, providing new business trends to our clients. In addition, we have very close cooperation relationships with many Chinese pharmaceutical factories. These pharmaceutical manufacturers have GMP regulated workshops, advanced production and testing equipments, first-class QC labs and a production team with rich experience. We can supply various Active Pharmaceutical Ingredients and finished products which meet EP/USP/BP standards. Chinese GMP, EU-GMP, COS/CEP certificates with DMF documents are available, and many products have been approved by FDA. We believe that quality and innovation are vital for an enterprise. Adhering to the business philosophy of integrity and win-win cooperation, Sinoway is looking forward to have a bright future with you together.

You may like

Recommended supplier

Product name Price   Suppliers Update time
$850.00/100g
VIP1Y
hebei hongtan Biotechnology Co., Ltd
2024-05-11
$25.00/1box
VIP1Y
Shanghai Getian Industrial Co., LTD
2024-04-24
$1000.00/1000kg
VIP1Y
Guangdong Tuoyuan Biotechnology Co., LTD
2024-04-07
$3.00/1kg
VIP1Y
Shanghai Aosiris new Material Technology Co., LTD
2024-03-29
$15.00/1bottle
VIP1Y
Sigma Audley
2024-01-19
$0.00/1kg
Wuhan Han Sheng New Material Technology Co.,Ltd
2023-12-25
$40.00/1Box
VIP1Y
zhuzhou dingcheng meihei comestic co.,ltd
2023-12-07
$30.00/1KG
VIP2Y
Firsky International Trade (Wuhan) Co., Ltd
2023-09-28
$0.00/25kg
VIP1Y
Shaanxi Haibo Biotechnology Co., Ltd
2023-09-05
$30.00/1kg
Anhui Ruihan Technology Co., Ltd
2023-08-17
  • Since: 1996-07-16
  • Address: Fujian China ,16F, Huicheng Comm. Complex, 839 Xiahe RD.
INQUIRY