2,4,5-Trichlorophenoxyacetic acid

Acute toxicity - Category 4, Oral

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity – single exposure, Category 3

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

H225 Highly Flammable liquid and vapour

H302 Harmful if swallowed

H312 Harmful in contact with skin

H315 Causes skin irritation

H319 Causes serious eye irritation

H332 Harmful if inhaled

H335 May cause respiratory irritation

H410 Very toxic to aquatic life with long lasting effects

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P273 Avoid release to the environment.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501 Dispose of contents/container to..…

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P273 Avoid release to the environment.

P301+P317 IF SWALLOWED: Get medical help.

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P321 Specific treatment (see ... on this label).

P332+P317 If skin irritation occurs: Get medical help.

P362+P364 Take off contaminated clothing and wash it before reuse.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P319 Get medical help if you feel unwell.

P391 Collect spillage.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .

Overexposure to dust by inhalation or ingestion may cause fatigue, nausea, vomiting, lowered blood pressure, convulsions, coma. Dust may irritate eyes and skin. (USCG, 1999)

2,4,5-T given orally to ... volunteers in doses of 100-150 mg was readily absorbed and gradually eliminated from blood plasma, showing first-order elimination rate; more than 80% of dose was excreted in urine in intact form within 72 hr. Daily urinary excretion ... in exposed workers was found to range from 0.5-3.6 mg/day in 11/21 samples.

Wear/ self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode /when fighting fire/.

Special Hazards of Combustion Products: Toxic hydrogen chloride and phosgene gases may be formed. (USCG, 1999)

Use water spray, powder.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

1. ventilate area of spill. 2. collect spilled material in the most convenient and safe manner and deposit in sealed containers for reclamation, or for disposal in a secured sanitary landfill. liquid containing 2,4,5-t should be absorbed in vermiculite, dry sand, earth, or a similar material.

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Store in an area without drain or sewer access.DO NOT STORE NEAR OTHER AGROCHEMICALS OR SEEDS. DO NOT STORE IN FREEZING TEMPERATURES.

TLV: 10 mg/m3, as TWA; A4 (not classifiable as a human carcinogen).MAK: (inhalable fraction): 2 mg/m3; peak limitation category: II(2); skin absorption (H); pregnancy risk group: C

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear safety goggles.

Protective gloves.

Use local exhaust or breathing protection.

no data available

Decomposes on heating and on burning. This produces toxic and corrosive gases including phosgene (see ICSC 0007) and hydrogen chloride (see ICSC 0163). The solution in water is a weak acid.

Stable @ its melting-point

Material does not burn or burns with difficulty.2,4,5-TRICHLOROPHENOXYACETIC ACID is a weak acid. Reacts with organic and inorganic bases to form water-soluble salts and with alcohols to form esters. Incompatible with strong oxidizing agents and strong bases. Can corrode metals, especially if moist. May harm painted surfaces (NTP, 1992).

no data available

STABILITY: This chemical is stable under normal laboratory conditions. It is stable in aqueous solution at pH 5-9. Solutions of this chemical in water, DMSO, 95% ethanol or acetone should be stable for 24 hours under normal laboratory conditions.REACTIVITY: This chemical forms water-soluble salts with alkali metals and amines. It reacts with organic and inorganic bases to form salts and with alcohols to form esters. It is incompatible with strong oxidizing agents and strong bases. It can be corrosive to common metals. It may be deleterious to painted surfaces. Precipitation occurs with hard water in the absence of sequestering agents. (NTP, 1992)

Toxic gases and vapors /which include/: hydrogen chloride and carbon monoxide.

no data available

no data available

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no data available

Classification of carcinogenicity: 1) evidence in humans: limited; Overall summary evaluation of carcinogenic risk to humans is Group 2B: The agent is possibly carcinogenic to humans. Chlorophenoxy herbicides; From table

no data available

The substance is irritating to the eyes and respiratory tract.

Animal tests show that this substance possibly causes toxicity to human reproduction or development.

A harmful concentration of airborne particles can be reached quickly on spraying or when dispersed, especially if powdered.

Aerobic degradation of 10 ug 2,4,5-T of soil was 5-35% in unsterilized tropical clay and silty clay soils and <1% in sterilized soils after 4 months incubation(1). In Vietnamese soils, 64-69% aerobic degradation of 1 ppm 2,4,5-T occurred in 49 days, 74-96% aerobic degradation of 15 ppm 2,4,5-T occurred in 168 days and no degradation was observed in sterilized soils(2). The primary degradation product of 2,4,5-T in aqueous and soil systems is 2,4,5-trichlorophenol(3). Aerobic metabolism of 2,4,5-T leads to formation of 2,4,5-trichlorophenol and 3,5-dichlorocatechol which may further degrade to 4-chlorocatechol or cis,cis-2,4-dichloromuconic acid, 2-chloro-4-carboxy-methylene-but-2-enolide, chlorosuccinic acid and succinic acid(2). Degradation under anaerobic conditions has led to the formation of di- and mono-chlorophenols and 2,5-dichlorophenoxyacetic acid(4,5). Anaerobic degradation occurs much more slowly than aerobic degradation(6).

The bioconcentration factor (BCF) of 2,4,5-T in static ecosystem tests has been measured to be 23-25 in fish(1,2). Under flowing water conditions its estimated BCF in fish is 43(1). Based on these BCF values, bioconcentration in aquatic organisms should not be significant.

Measured soil adsorption coefficient (Koc) values for 2,4,5-T in various soils are as follows: 86-sand, 186-whole soil, 204-fines, 205-coarse clay, 206-coarse silt and 280-medium silt(1). Measured soil TLC Rf values are as follows: 0.17-muck, 0.48-clay, 0.54-silt clay loam and 0.73-0.89-sandy loam(2). These Koc and Rf values indicate that 2,4,5-T mobility in soil should vary from highly mobile in sandy soil to moderately mobile in clay and silt loams to slightly mobile in muck (3,4). Humic acids found in almost all water and soil systems have been shown to strongly adsorb 2,4,5-T from solution(5), and the tendency of 2,4,5-T to adsorb to soil has been observed to increase with increasing organic content in soil(6). When 11.2 kg/ha 2,4,5-T was applied to a large field lysimeter, 96-99% of the undegraded herbicide remained 0-10 cm deep and 0.33-3.7% remained between 10 to 30 cm deep after 2-3 winters(7). Up to 8 weeks following application of 1 g/cu m 2,4,5-T, 86-98% of the undegraded 2,4,5-T applied to arable land remained within the top 30 cm of the soil layer and 84-100% remained within the top 10 cm of forest soil(8).

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN3077 (For reference only, please check.)

IMDG: UN3077 (For reference only, please check.)

IATA: UN3077 (For reference only, please check.)

ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)

IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)

IATA: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)

ADR/RID: 9 (For reference only, please check.)

IMDG: 9 (For reference only, please check.)

IATA: 9 (For reference only, please check.)

ADR/RID: III (For reference only, please check.)

IMDG: III (For reference only, please check.)

IATA: III (For reference only, please check.)

ADR/RID: Yes

IMDG: Yes

IATA: Yes

no data available

no data available

Temperature of decomposition is unknown in the literature.Commercial products may contain toxic dioxin (see ICSC 1467 2,3,7,8-TCDD).If the substance is formulated with solvents also consult the ICSCs of these materials.Carrier solvents used in commercial formulations may change physical and toxicological properties.The recommendations on this card also apply to salts of 2,4,5-Trichlorophenoxyacetic acid.