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ChemicalBook CAS DataBase List 1,2,3,4,5,6-Benzenehexamine-3HCl

1,2,3,4,5,6-Benzenehexamine-3HCl synthesis

8synthesis methods
1,2,3,4,5,6-Benzenehexamine-3HCl can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly in laboratory research and development. It was prepared from 2,4,6-triazo-p-tolyl-1,3,5-triamino Benzene with  Tin dichloride by stirring in ethyl acetate for 2 h at 90℃.
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: sulfuric acid; sulfur trioxide; potassium nitrate
2: ammonia / toluene / Heating
3: methanol; ammonia; sodium / Cooling

References:

Juarez, Rafael;Ramos, Mar;Segura, Jose L.;Orduna, Jesus;Villacampa, Belen;Alicante, Raquel [Journal of Organic Chemistry,2010,vol. 75,# 22,p. 7542 - 7549]

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