ChemicalBook CAS DataBase List 1,3-Diphenylacetone

1,3-Diphenylacetone synthesis

8synthesis methods

Product Name:1,3-Diphenylacetone
CAS Number:102-04-5
Molecular formula:C15H14O
Molecular Weight:210.27

By heating α,?α’-phenyl benzyl ethylene glycol or α,?α’-phenyl benzyl ethylene oxide in the presence of diluted H2SO4 or ZnCl2; also by dry distillation of phenylacetate and magnesium chloride (C6H5CH2COOMgCl) or other salts of phenylacetic acid.

100-39-0
424 suppliers
$10.00/10 g

103-80-0
310 suppliers
$13.00/25g

102-04-5
288 suppliers
$9.00/10g

Yield:102-04-5 41 mmol

Reaction Conditions:

with bis(1,5-cyclooctadiene)nickel⁽⁰⁾;magnesium chloride;zinc in acetonitrile at 20; for 12 h;Inert atmosphere;

Steps:

1.1 Step1
To just from the blast oven out of the three bottles of brominated Bian 100mmol,Anhydrous magnesium chloride 1.5 equivalents,Ligand bipyridine 0.15 equivalents,Activated Zinc Powder 3 Equivalent.Under nitrogen protection,Adding Ni (COD) 2 0.1 equivalent,After the next nitrogen protection,Add solvent acetonitrile,withAcid chloride.Reaction at room temperature for 12 h.After completion of the reaction,By column chromatography,Get the product41 mmol (1-1)

References:

Changchun Hai Purunsi Technology Co., Ltd.;Sun Keyi;Cai Hui CN107235858, 2017, A Location in patent:Paragraph 0032; 0034