ChemicalBook CAS DataBase List 1-AMino-6-Methoxyisoquinoline

1-AMino-6-Methoxyisoquinoline synthesis

7synthesis methods

Product Name:1-AMino-6-Methoxyisoquinoline
CAS Number:266690-48-6
Molecular formula:C10H10N2O
Molecular Weight:174.2

132997-77-4
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$65.00/100mg

266690-48-6
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$200.00/50mg

Yield: 72%

Reaction Conditions:

with copper(I) oxide;ammonia in ethylene glycol at 120; for 72 h;

Steps:

83.F
[00308] A sealable tube was charged with 83E (770 mg, 3.98 mmol), copper (I) oxide (30 mg) and ~12M NH3 in ethylene glycol (5 mL). The tube was sealed and the reaction was heated to 120 °C for 72 h. After cooling to rt, the reaction was diluted EPO with methanol and was purified via preparative HPLC (MeOH/water/TFA) to provide 83F (832 mg, 72%). LC-MS: 175.23 (M + H)⁺.

References:

BRISTOL-MYERS SQUIBB COMPANY WO2006/76246, 2006, A2 Location in patent:Page/Page column 150-153

266690-47-5 Synthesis