ChemicalBook CAS DataBase List 1-Boc-3-oxopiperazine

1-Boc-3-oxopiperazine synthesis

4synthesis methods

Product Name:1-Boc-3-oxopiperazine
CAS Number:76003-29-7
Molecular formula:C9H16N2O3
Molecular Weight:200.23

5625-67-2 Synthesis

5625-67-2
335 suppliers
$5.00/1g

24424-99-5 Synthesis

24424-99-5
816 suppliers
$13.50/25G

76003-29-7
243 suppliers
$5.00/5g

Yield:76003-29-7 100%

Reaction Conditions:

in dichloromethane for 3 h;

Steps:

33
To a mixture of piperazine-2-one (1.037 g, 10.4 mmol) in 52 mL of CH2Cl2, was added BOC20 (2.5 g, 11.4 mmol). The reaction became homogeneous after 3 hours when the starting material was completely consumed. The reaction was diluted with CH2Cl2 and the organic layer was washed with water. The solvent was removed in vacuo to yield quantitative amount of product 33 as a white solid. ¹H NMR (300 MHz, CDCl3) 8 1.48 (s, 9H), 3.35-3.44 (m, 2H), 3.64 (t, 2H, J= 5 Hz), 4.10 (s, 2H), 6.41 (br s, 1H).

References:

GILEAD SCIENCES, INC.;CAI, Zhenhong, R.;CHEN, Xiaowu;FARDIS, Maria;JABRI, Salman, Y.;JIN, Haolun;KIM, Choung, U.;METOBO, Sanuel, E.;MISH, Michael, R.;PASTOR, Richard, M. WO2005/117904, 2005, A2 Location in patent:Page/Page column 407

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24424-99-5 Synthesis

24424-99-5
816 suppliers
$13.50/25G

105-39-5 Synthesis