ChemicalBook CAS DataBase List 1-BROMO-2,4-DICHLOROBENZENE

1-BROMO-2,4-DICHLOROBENZENE synthesis

6synthesis methods

Product Name:1-BROMO-2,4-DICHLOROBENZENE
CAS Number:1193-72-2
Molecular formula:C6H3BrCl2
Molecular Weight:225.9

541-73-1 Synthesis

541-73-1
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1193-72-2
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$9.00/5g

Yield:1193-72-2 98.5%

Reaction Conditions:

with bromine;iron(III) chloride

Steps:

1 EXAMPLE 1
EXAMPLE 1 In a 1,000 ml four necked flask equipped with a reflux condenser, a dropping funnel, a thermometer and a stirrer, 588 g (4 mole) of metadichlorobenzene and 8 g of ferric chloride were charged, and 640 g (4 mole) of bromine was added dropwise to the mixture at room temperature with stirring. The reaction was carried out for about 3 hours. After the reaction, the reaction mixture was poured into water and it was neutralized with sodium hydroxide. The reaction product was extracted with chloroform. The extract was washed with water and dried and was distilled under a reduced pressure to obtain 890 g of 1-bromo-2,4-dichlorobenzene (yield: 98.5%). The dropping funnel was replaced with a gas inlet tube. The reflux condenser and the flask were cooled with acetone and dry-ice from outside.

References:

Ishihara Sangyo Kaisha Ltd. US4138436, 1979, A

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5446-18-4 Synthesis