1-(Bromomethyl)-2-chloro-3,4-dimethoxybenzene synthesis
- Product Name:1-(Bromomethyl)-2-chloro-3,4-dimethoxybenzene
- CAS Number:848696-72-0
- Molecular formula:C9H10BrClO2
- Molecular Weight:265.53
93983-13-2
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848696-72-0
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Yield:848696-72-0 94%
Reaction Conditions:
with phosphorus tribromide in diethyl ether at 20; for 2 h;
Steps:
209.a
PBr3 (0.13 g, 0.5 tnmol) was added dropwise to a solution of [2-chloro-3,4- bis(methyloxy)phenyl]methanol (0.404 g, 2 mmol) in Et2O (10 mL) and the reaction was stirred at RT for 2 h. NaHCO3 was added and the reaction was extracted with Et2O. The organic layer was dried over MgSO4 and concentrated to yield the crude product (0.5 g, 94%). 1H-NMR (CDCl3) δ : 3.903 (d, 6H, J= 2.8 Hz), 4.619 (s, 2H), 6.831 (d, IH, J= 8.4 Hz ), 7.189 (d, IH, J= 8.8 Hz).
References:
WO2007/65093,2007,A2 Location in patent:Page/Page column 122
5417-17-4
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848696-72-0
11 suppliers
$332.00/1g