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1-Chloro-7-methylnaphthalene synthesis

7synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: SOCl2, DMF / CH2Cl2 / 18 h
2: AlCl3 / CH2Cl2 / 0.25 h / -10 °C
3: TiCl4 / CH2Cl2; tetrahydrofuran / 2 h / 0 °C
4: Ph3COH, TFA / 48 h / Ambient temperature

References:

Ellingboe, John W.;Lombardo, Louis J.;Alessi, Thomas R.;Nguyen, Thomas T.;Guzzo, Frieda;et al. [Journal of Medicinal Chemistry,1993,vol. 36,# 17,p. 2485 - 2493]