ChemicalBook CAS DataBase List 2-Benzyl-2-(dimethylamino)-4'-morpholinobutyrophenone

2-Benzyl-2-(dimethylamino)-4'-morpholinobutyrophenone synthesis

9synthesis methods

Product Name:2-Benzyl-2-(dimethylamino)-4'-morpholinobutyrophenone
CAS Number:119313-12-1
Molecular formula:C23H30N2O2
Molecular Weight:366.5

110-91-8 Synthesis

110-91-8
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1-Butanone, 2-(dimethylamino)-1-(4-fluorophenyl)-2-(phenylmethyl)-

119312-61-7
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2-Benzyl-2-(dimethylamino)-4'-morpholinobutyrophenone

119313-12-1
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$6.00/5g

Yield:119313-12-1 85%

Reaction Conditions:

in 1,2-dichloro-ethaneReflux;Solvent;

Steps:

9 Example 9; preparation of 2-benzyl-2-dimethylamino-1-(4-morpholino phenyl)-1-butanone
take 2-benzyl-2-dimethylamino-1-P-fluorophenyl-1-butanone dissolve in dichloroethane solution and add morpholine (139.6g, 1 . 6mol) into 1L in four-mouth bottle, heating reflux reaction, TLC or liquid phase chromatographic monitoring reaction, after the reaction is complete, reducing the temperature to room temperature, add 200 ml water washing, stirring 0.5h, layering, the organic phase is separated, and recovering the solvent, by residues 440 ml ethanol is recrystallized to get pale yellow solid 117.2, melting point: 115-116°C, the overall yield is 80%, purity 99.3%

References:

Shandong Chemical Technology Co., Ltd. day long;Zhang, Qi;Luo, Xian;Wu, Rui;Wang, Tao;Lui, Changwei;Li, Yilin;Li, Hongzhou;Li, Ke;Luzhen, Bo;Zhao, Guofeng CN105384707, 2016, A Location in patent:Paragraph 0003; 0034

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