TRANS-4-(TRIFLUOROMETHYL)CYCLOHEXANECARBOXYLIC ACID synthesis

Yield:50 % de

Reaction Conditions:

with [Rh(cod)(CI)(CAAC^Me₂)];hydrogen in hexane at 40; under 45004.5 Torr; for 24 h;Molecular sieve;Overall yield = 98 percent;

Steps:

11 Example 1

General procedure: Add 131 mg (0.5 mmol) of tert-butyl (2- (trifluoromethyl) phenylamino) formate, 3 mg (0.005 mmol) to the reaction flask.Cyclic (alkyl) (amino) carbene complex catalyst of rhodium, 125mg 4 A 5mL hexane, 5MPa into hydrogen and stirred for 24 hours at 40 .After the reaction, the solution was filtered, washed with dichloromethane, and then subjected to silica gel column chromatography (eluent was a mixture of petroleum ether and ethyl acetate in a volume ratio of 20: 1).(2- (trifluoromethyl) cyclohexylamino) carboxylic acid tert-butyl ester was obtained in a yield of 98%, d.r. = 91: 9.

References:

CN110330400,2019,A Location in patent:Paragraph 0021-0023; 0052-0054