1,2,3,4-tetrahydro-2,3-dioxoquinoxaline-6-carboxylic acid synthesis
- Product Name:1,2,3,4-tetrahydro-2,3-dioxoquinoxaline-6-carboxylic acid
- CAS Number:14121-55-2
- Molecular formula:C9H6N2O4
- Molecular Weight:206.15
144-62-7
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619-05-6
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14121-55-2
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$50.00/250mg
Yield:14121-55-2 88%
Reaction Conditions:
Stage #1: oxalic acidwith choline chloride at 100; for 0.5 h;
Stage #2: 3,4-diaminobenzoic acid at 100; for 2 h;
Steps:
General procedure for preparation of quinoxaline-2,3-diols using DES-1(Method 1)
General procedure: A mixture of choline chloride (0.28 g, 2 mmol) and oxalic acid dihydrate (0.25 g,2 mmol) was stirred and heated to 100 C for ca. 30 min to form DES-1. Arene-1,2-diamine (1.4 mmol) was added to the eutectic mixture and stirred for 2 h at 100 C. Hotwater (20 mL) was added to the resulting reaction mixture with rapid stirring. The precipitatedsolid was collected by filtration and recrystallized from ethanol to afford thepure quinoxaline-2,3-diol 1.
References:
Aghapoor, Kioumars;Mohsenzadeh, Farshid;Darabi, Hossein Reza;Sayahi, Hani [Organic Preparations and Procedures International,2022,vol. 54,# 2,p. 157 - 166]
95-92-1
405 suppliers
$5.00/5G
619-05-6
289 suppliers
$19.00/25g
14121-55-2
28 suppliers
$50.00/250mg