2,4(1H,3H)-Pyrimidinedione, 5-fluoro-6-methyl- (9CI) synthesis

3synthesis methods

Product Name:2,4(1H,3H)-Pyrimidinedione, 5-fluoro-6-methyl- (9CI)
CAS Number:1480-99-5
Molecular formula:C5H5FN2O2
Molecular Weight:144.1038

626-48-2 Synthesis

626-48-2
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2,4(1H,3H)-Pyrimidinedione, 5-fluoro-6-methyl- (9CI)

1480-99-5
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Yield:1480-99-5 37%

Reaction Conditions:

with Selectfluor in water at 80; for 4 h;

Steps:

General procedure: Fluorination of 6-methyl- and 1,3,6-trimethyluracils1 and 2 (general procedure). A solution ofuracil 1 or 2 and F-TEDA-BF4 in water was stirredunder the conditions indicated in table, the solvent waspurged off with a stream of air, the residue was dissolvedin DMSO-d6, and 1H and 19F NMR spectra wererecorded. In some cases (see table), excess F-TEDABF4was removed by adding KI and Na2S2O3 to thereaction mixture before purging with air.

References:

Borodkin;Elanov;Shubin [Russian Journal of Organic Chemistry,2015,vol. 51,# 7,p. 1003 - 1007][Zh. Org. Khim.,2015,vol. 51,# 7,p. 1021 - 1025,5]

5-Fluoro-2-methoxy-6-methylpyrimidin-4(1H)-one

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1480-99-5
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References

4(3H)-Pyrimidinone, 2-(ethylthio)-5-fluoro-6-methyl-

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1480-99-5
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References