ChemicalBook CAS DataBase List Methyl 2-(4-(4-chlorobutanoyl)phenyl)-2-methylpropanoate

Methyl 2-(4-(4-chlorobutanoyl)phenyl)-2-methylpropanoate synthesis

13synthesis methods

Product Name:Methyl 2-(4-(4-chlorobutanoyl)phenyl)-2-methylpropanoate
CAS Number:154477-54-0
Molecular formula:C15H19ClO3
Molecular Weight:282.76

DIMETHYLKETENE METHYL TRIMETHYLSILYL ACETAL

31469-15-5
170 suppliers
$38.00/5g

4559-96-0 Synthesis

4559-96-0
55 suppliers
$30.00/10g

Methyl 2-(4-(4-chlorobutanoyl)phenyl)-2-methylpropanoate

154477-54-0
174 suppliers
$115.00/500 mg

Yield:154477-54-0 85%

Reaction Conditions:

with zinc(II) fluoride;bis(acetylacetonato)palladium(II);tri-tert-butyl phosphine in DMF (N,N-dimethyl-formamide) at 80;Product distribution / selectivity;

Steps:

9
EXAMPLE 9; Two grams of 20, 170 mg of P(tBu)₃, 560 mg of Pd(acac)₂, 474 mg of ZnF₂and 2.0 g of 5 were combined in 50 mL of DMF under argon. The mixture was heated to 80° C. and monitored by HPLC. When reaction was complete, the mixture was cooled to room temperature and 250 mL of water was added. The mixture was extracted three times with ether, dried, filtered and reduced in vacuo. The resulting product was flash chromatographed in 4:1 hexane-ethyl acetate to provide 1.89 g (85%) of 8.

References:

AMR Technology, Inc. US2006/63933, 2006, A1 Location in patent:Page/Page column 12; 21

FullText