ChemicalBook CAS DataBase List (R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate

(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate synthesis

11synthesis methods

Product Name:(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate
CAS Number:174649-09-3
Molecular formula:C15H19FN2O6S
Molecular Weight:374.38

124-63-0
6 suppliers
$10.00/5g

168828-82-8 Synthesis

(5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione

168828-82-8
236 suppliers
$5.00/250mg

(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate

174649-09-3
156 suppliers
$39.00/25mg

Yield: 100%

Reaction Conditions:

with triethylamine in dichloromethane at 0; for 0.5 h;

Steps:

5
To a solution of 132.8 g of (R)-N-[[3-[3-fluoro-4-morpholinyl]phenyl]-2-oxo-5- oxazolidinyl] methanol and 87.1 g of triethylamine in IL of methylene dichloride at O⁰C under nitrogen was added 74 gm of methanesulfonyl chloride. The reaction mixture was allowed to stir at 0°C for 30 min, then allowed to warm to ambient temperature. A white solid was precipitated. 1.75 L water, 6.50 L methylene dichloride and IL ethyl acetate mixture were added followed by stirring for 30 min. The reaction mass was filtered to get a white solid. Yield: 140 g.; Percentage: 105.42% w/w

References:

USV LIMITED WO2009/63505, 2009, A2 Location in patent:Page/Page column 14

369-34-6 Synthesis