ChemicalBook CAS DataBase List 1H,1H,2H,2H-PERFLUORO-1-OCTANOL

1H,1H,2H,2H-PERFLUORO-1-OCTANOL synthesis

11synthesis methods

Product Name:1H,1H,2H,2H-PERFLUORO-1-OCTANOL
CAS Number:647-42-7
Molecular formula:C8H5F13O
Molecular Weight:364.1

2043-57-4 Synthesis

1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane

2043-57-4
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647-42-7
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Yield:647-42-7 88%

Reaction Conditions:

with water in N,N-dimethyl-formamide at 125 - 130; under 2625.26 Torr; for 32 h;Large scale;Green chemistry;

Steps:

2.2; 4

(2) In another 20 liters of pressure-resistant reactor, 2000 g of perfluorohexylethyl iodide obtained in (1) was added, and the mixture was heated to 125 ° C with stirring. 6000 g of 4% aqueous dimethylformamide was added to the reactor at a rate of 80 g/min by a metering pump, and the temperature was controlled at 125 to 130 ° C, the pressure was not higher than 0.35 MPa, and the reaction was continued for 32 hours, and the heating was removed. Neutralize with 2222 g of 11.3% potassium hydroxide aqueous solution, separate the organic phase, and then wash once with 2222 g of deionized water, separate the organic phase, and remove the light component to obtain 1420 g of fluoroalcohol 88% and fluorinated olefin 5.5%. Intermediate product.

References:

CN108911983,2018,A Location in patent:Paragraph 0024; 0027

355-43-1 Synthesis