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ChemicalBook CAS DataBase List (1R,2R)-(-)-1,2-Diaminocyclohexane

(1R,2R)-(-)-1,2-Diaminocyclohexane synthesis

2synthesis methods
L-trans-1,2-cyclohexanediamine is a chiral auxiliary; a raw material for the synthesis of other organic chiral reagents and an oxaliplatin intermediate.
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: acetic acid / water / 5 - 90 °C
2: sodium chloride; sodium hydroxide / dichloromethane; water / 0.5 h

References:

Cooper, Christine J.;Jones, Matthew D.;Brayshaw, Simon K.;Sonnex, Benjamin;Russell, Mark L.;Mahon, Mary F.;Allan, David R. [Dalton Transactions,2011,vol. 40,# 14,p. 3677 - 3682]

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