2-[(1-methyl-2-phenoxyethyl)amino]ethanol synthesis
- Product Name:2-[(1-methyl-2-phenoxyethyl)amino]ethanol
- CAS Number:103-39-9
- Molecular formula:C11H17NO2
- Molecular Weight:195.26
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
Yield: 77%
Reaction Conditions:
at 110 - 115; for 2 h;
Steps:
2 Example 2: Synthesis of N-(phenoxyisopropyl)-ethanolamine
Mono ethanolamine (30.0 g; 0.491moles) and l-Phenoxypropane-2-yl-4- methylbenzene sulphonate (50.0 g; 0.163 moles) were heated to 1 10-1 15 °C and stirred for 2 hours. Then the reaction mass cooled to 30-35°C and dichloromethane (100 ml) and D.M. water (50 ml) were added while stirring. Organic layer was concentrated under reduced at 30-35°C and the obtained residue was dissolved in MTBE and allowed to cool to obtain the solid product which was filtered and dried under vacuum at 45-50°C to afford N- (phenoxyisopropyl)-ethanolamine. (77 % yield; >98 % HPLC purity)
References:
AUROBINDO PHARMA LIMITED;TIWARI, Shashi Kant;CHENNURI, Rajesh;SAMALA, Bhanuchandar;KINTALI, Venkata Ramana;MEENAKSHISUNDERAM, Sivakumaran WO2018/130942, 2018, A1 Location in patent:Page/Page column 10; 12
770-35-4
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103-39-9
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