2-(1H-PYRAZOL-3-YL)PYRIDINE synthesis
- Product Name:2-(1H-PYRAZOL-3-YL)PYRIDINE
- CAS Number:75415-03-1
- Molecular formula:C8H7N3
- Molecular Weight:145.16
75415-00-8
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75415-03-1
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Yield:75415-03-1 97.3%
Reaction Conditions:
with hydrazine hydrate in ethanol at 60; for 0.5 h;
Steps:
15 Synthesis of 2-(3-pyrazolyl)pyridine (17a)
Example 15
Synthesis of 2-(3-pyrazolyl)pyridine (17a)
Compound 16a (1 g, 6.2 mmol) obtained from the aforesaid process and hydrazine hydrate (2 mL) were dissolved in ethanol (3.3 mL), and reacted at 60° C. for 0.5 hour.
Then, the mixture was cooled to room temperature, and then the solvent was removed in vacuum to afford the product 17a (874.7 mg) as a faint yellow solid, with a yield of 97.3%.
1H-NMR (400 MHz, CDCl3): δ 8.66 (d, J=4.8 Hz, 1H), 7.75 (d, J=3.6 Hz, 2H), 7.67 (d, J=2 Hz, 1H), 7.23-7.27 (m, 1H), 6.81 (d, J=2 Hz, 1H).
References:
SI CHUAN UNIVERSITY;SICHUAN GOODDOCTOR PHARMACEUTICAL GROUP CO., LTD;Luo, Youfu;Wang, Zhenling;Wei, Yuquan;Geng, Funeng US2014/142144, 2014, A1 Location in patent:Paragraph 0235; 0236; 0237
1122-62-9
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4637-24-5
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75415-03-1
156 suppliers
$12.00/250mg
1122-62-9
544 suppliers
$7.00/10g
75415-03-1
156 suppliers
$12.00/250mg