2,2-DIMETHYL-5-NITRO-1,3-DIOXANE synthesis
- Product Name:2,2-DIMETHYL-5-NITRO-1,3-DIOXANE
- CAS Number:4064-87-3
- Molecular formula:C6H11NO4
- Molecular Weight:161.16
4728-14-7
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Yield:4064-87-3 92%
Reaction Conditions:
Stage #1: 2,2-dimethyl-5-hydroxymethyl-5-nitro-1,3-dioxanewith sodium hydroxide in water at 60; for 1 h;
Stage #2: with acetic acid in water at 5; pH=5;
Steps:
2
5-Nitw-2,2-dimethyl-l,3-dioxane is made by mixing 5-nitro-2,2-dimethyl-5- hydroxymethyl-l,3-dioxane (0.03 moles) with about 70 mL of 10 wt. % sodium hydroxide solution, and the solution is stirred at 60°C for about 60 minutes. The solution is cooled to about 5°C, and is acidified to pH 5 with concentrated acetic acid. The precipitated solid is filtered off and dried to give a 92% yield of product.
References:
WO2012/138494,2012,A1 Location in patent:Page/Page column 8
60766-57-6
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4064-87-3
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