2-(4-Aminophenyl)ethanol synthesis
- Product Name:2-(4-Aminophenyl)ethanol
- CAS Number:104-10-9
- Molecular formula:C8H11NO
- Molecular Weight:137.18
100-27-6
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104-10-9
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Yield:104-10-9 99.7%
Reaction Conditions:
with hydrogenchloride;hydrazine hydrate;sodium hydroxide in methanol;water at 68; pH=7;Reagent/catalyst;pH-value;
Steps:
1-10 Example 1
Intermediate 4-amino ethanol synthesis method, characterized in that the method comprises the following steps: Step 1, is provided with a thermometer to, mechanical stirring, reflux condenser 1000 ml three-port flask, add 10 ml concentration 0.1 M hydrochloric acid solution, 500 ml methanol and 2 g catalyst Pt - SnO2 /C, heating up to 68 °C; Step 2, to the ethanol solution is added to the nitrobenzene ethanol 100 g, for 30% concentration NaOH to adjust the pH=7, after stir slowly dropping water gathers jing 75 g, heating to reflux, the reflux temperature is 68 °C; Step 3, thin-layer chromatography monitoring reaction, to point the disappearance of the raw material, the end of the reaction, the reaction mixture is filtered to remove cooling and outputs Catalyst, normal pressure distillation recovery methanol; Step 4, the above-mentioned mixed system is cooled to 20 °C, adding proper amount of water and a small amount of NaOH solution, by freezing, vacuum drying to obtain white 4-amino ethanol.
References:
CN108840802,2018,A Location in patent:Paragraph 0008; 0021-0029
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104-10-9
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