2-(4-Fluorophenyl)-thiophene synthesis
- Product Name: 2-(4-Fluorophenyl)-thiophene
- CAS Number:58861-48-6
- Molecular formula:C10H7FS
- Molecular Weight:178.23
1003-09-4
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1765-93-1
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$9.00/1g
58861-48-6
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$8.00/1g
Yield:58861-48-6 85%
Reaction Conditions:
with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;potassium carbonate in N,N-dimethyl-formamide at 120; for 15 h;Inert atmosphere;
Steps:
4.1 1. Preparation of 2- (4-fluorophenyl) thiophene
A solution of 4.98 g (36 mmol) of 4-fluorobenzeneboronic acid, 4.1 g (30 mmol) of 2-bromothiophene and 10.98 g (60 mmol) of anhydrous potassium carbonate was dissolved in 20 mL of DMF and 24 mg (0.5% (Diphenylphosphino) ferrocene] palladium dichloride, heated to 120 ° C under nitrogen protection, quenched by constant temperature for 15 h, quenched by adding 30 mL of distilled water, treated with 30 mL CH2Cl2Extracted twice, the combined organic phase, anhydrous Na2SO4Dried and evaporated to dryness. The residue was diluted with petroleum ether and the filtrate was filtered to obtain a pale green filtrate. The filtrate was evaporated to dryness. The residue was purified by silica gel column chromatography using petroleum ether as eluent to give 2- (4-fluorophenyl) Thiophene 4.50 g, the yield was 85%.
References:
Shaanxi Normal University;Li, Baolin;Cui, Yi;Li, Xiabing;Wang, Wei CN106748970, 2017, A Location in patent:Paragraph 0098; 0099; 0100
6165-68-0
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460-00-4
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58861-48-6
352 suppliers
$8.00/1g
1003-09-4
467 suppliers
$10.00/25g
460-00-4
605 suppliers
$6.00/10g
58861-48-6
352 suppliers
$8.00/1g
1003-09-4
467 suppliers
$10.00/25g
352-13-6
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$40.00/50 mL
58861-48-6
352 suppliers
$8.00/1g