2,5-Dimethoxycinnamic acid synthesis
- Product Name:2,5-Dimethoxycinnamic acid
- CAS Number:10538-51-9
- Molecular formula:C11H12O4
- Molecular Weight:208.21
79-10-7
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Yield: 51%
Reaction Conditions:
with dipotassium peroxodisulfate;palladium diacetate in 1,4-dioxane;acetic acid at 80; for 24 h;Fujiwara Arylation Carboxylation;
Steps:
General procedure for the synthesis of compounds
General procedure: Typical coupling procedure: Pd(OAc)2 (22 mg, 5 mol%), K2S2O8 (0.81 g 3 mmol), alkene (2 mmol), arene (15 mmol, 7.5 equiv.), acetic acid (8 mL) and cosolvent (2 mL) were placed in a 20 mL scintillation vial containing a magnetic stirrer bar. The flask was sealed with a Teflon-lined crimped cap, and the reaction solution was stirred vigorously at 80 °C 24 h (unless otherwise specified). The reaction solution was cooled to room temperature, CH2Cl2 added, filtered and the solvent removed in vacuo. The residue was purified by column chromatography on silica gel using cyclohexane/ethyl acetate to afford the desired product.
References:
Jones, Roderick C. [Tetrahedron Letters,2020,vol. 61,# 6,art. no. 151471] Location in patent:supporting information
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10538-51-9
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$13.43/1gm:
108-24-7
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10538-51-9
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10538-51-9
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$13.43/1gm:
614-60-8
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10538-51-9
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$13.43/1gm: