ChemicalBook CAS DataBase List 2,6-BIS(TRIFLUOROMETHYL)PYRIDINE

2,6-BIS(TRIFLUOROMETHYL)PYRIDINE synthesis

4synthesis methods

Product Name:2,6-BIS(TRIFLUOROMETHYL)PYRIDINE
CAS Number:455-00-5
Molecular formula:C7H3F6N
Molecular Weight:215.1

626-05-1 Synthesis

626-05-1
498 suppliers
$9.00/10g

81290-20-2 Synthesis

81290-20-2
398 suppliers
$13.00/1g

455-00-5
126 suppliers
$9.00/250mg

Yield: 92%

Reaction Conditions:

Stage #1:(trifluoromethyl)trimethylsilane with silver fluoride in N,N-dimethyl-formamide at 20; for 0.333333 h;
Stage #2: with copper in N,N-dimethyl-formamide for 4 h;
Stage #3:2,6-Dibromopyridine in N,N-dimethyl-formamide at 75; for 4 h;

Steps:

4.2.2. Method B
General procedure: To a well stirred mixture of AgF (1.27 g, 10 mmol) in 10 ml of DMF, Me₃SiCF₃ (1.7 g, 12 mmol) was added at room temperature. The mixture was stirred for 20 min and copper powder (1.0 g, 15 mmol) was added. After stirring for 4 h, the formation of CuCF₃ was complete. The corresponding halogen containing compound (9 mmol) (in the case of 2,6-dibromopyridine, 4.5 mmol) was added and the reaction mixture was stirred under conditions surveyed in Table 1. The reaction was terminated unless signals of CuCF₃ were no longer detected in the ¹⁹F NMR spectra. The mixture was filtered from the solid precipitate and poured into 50 ml of water. The organic layer was extracted with diethyl ether and dried over MgSO₄. Ether was evaporated and the remainder was distilled under reduced pressure or crystallized.

References:

Kremlev, Mikhail M.;Mushta, Aleksej I.;Tyrra, Wieland;Yagupolskii, Yurii L.;Naumann, Dieter;Möller, Angela [Journal of Fluorine Chemistry,2012,vol. 133,p. 67 - 71] Location in patent:experimental part

499-83-2 Synthesis