2-Amino-5-chloro-3-nitropyridine synthesis
- Product Name:2-Amino-5-chloro-3-nitropyridine
- CAS Number:5409-39-2
- Molecular formula:C5H4ClN3O2
- Molecular Weight:173.56
1072-98-6
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5409-39-2
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$6.00/250mg
Yield:5409-39-2 67%
Reaction Conditions:
Stage #1:5-chloro-2-pyridylamine with sulfuric acid;nitric acid at 55; for 1.25 h;
Stage #2: with sodium hydroxide in water; pH=11
Steps:
A40.a
To a mixture of 2-amino-5-chloropyridine (2.57 g, 20.0 mmol) and sulfuric acid (6.30 ml), huming HNO3 (0.860 ml, 21.1 mmol) was added dropwise over 15 minutes at 55 °C and stirred at 55 "C for 1 hour. After cooling, the reaction mixture was poured into ice-water (60 g) and neutralized with aqueous NaOH solution (pH = 11). The precipitated material was collected, washed with H2O and dried under reduced pressure at 50 0C to give 5-chloro-3-nitropyridin-2-amine (2.31 g, 67 %, yellow solid).
References:
SHIONOGI & CO., LTD.;EURO-CELTIQUE S.A WO2008/8398, 2008, A2 Location in patent:Page/Page column 369
1072-98-6
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$5.00/1g
5409-39-2
226 suppliers
$6.00/250mg
6945-68-2
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31396-27-7
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5409-39-2
226 suppliers
$6.00/250mg
31396-27-7
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7664-93-9
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5409-39-2
226 suppliers
$6.00/250mg
1072-98-6
694 suppliers
$5.00/1g
7664-93-9
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7697-37-2
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5409-39-2
226 suppliers
$6.00/250mg