ChemicalBook CAS DataBase List 2-Amino-5-chlorobenzoic acid

2-Amino-5-chlorobenzoic acid synthesis

11synthesis methods

Product Name:2-Amino-5-chlorobenzoic acid
CAS Number:635-21-2
Molecular formula:C7H6ClNO2
Molecular Weight:171.58

2516-95-2 Synthesis

2516-95-2
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$5.00/5g

635-21-2
412 suppliers
$5.00/5g

Yield:635-21-2 96%

Reaction Conditions:

with hydrogen;nickel in ethanol at 20;

Steps:

3 Preparation of 2-Amino-5-chloro benzoic acid (Compound 57)
To a solution of 5-chloro-2-nitrobenzoic acid (20 g, 110 mmol) in ethanol was added freshly activated raney nickel (2 g). The mixture was stirred overnight at room temperature under hydrogen atmosphere. The solution was filtered through celite and evaporated under reduced pressure to yield 16 g (96%) of white SOLIDS. 1H NMR (DMSO-D6) : d 6.77 (d, J = 8.9 Hz, 1H), 7.24 (DD, J= 2.9, 8.9 Hz, 1H), 7.62 (d, J= 2.9 Hz, 1H), 8.7 (b, 3H); EIMS: 170 (M-H).

References:

AVANIR PHARMACEUTICALS WO2004/74218, 2004, A2 Location in patent:Page 115-116

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