ChemicalBook CAS DataBase List 2-AMINO-N-(4-CHLORO-PHENYL)-BENZAMIDE

2-AMINO-N-(4-CHLORO-PHENYL)-BENZAMIDE synthesis

11synthesis methods

Product Name:2-AMINO-N-(4-CHLORO-PHENYL)-BENZAMIDE
CAS Number:4943-86-6
Molecular formula:C13H11ClN2O
Molecular Weight:246.69

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Yield:4943-86-6 93%

Reaction Conditions:

with tetrahydroxydiboron;palladium on activated charcoal;water in acetonitrile at 50; for 24 h;Inert atmosphere;

Steps:

27 Example 27Synthesis of 2-amino-N-(4-chlorophenyl)benzamide

2-nitro-N-(4-chlorophenyl)benzamide (0.6mmol, 166.0mg), water (6mmol, 108.0mg), Pd/C (0.03mmol, 6.4mg) and tetrahydroxydiboron (1.98 mmol, 177.5mg), acetonitrile (1mL), react at 50°C for 24h under nitrogen protection, monitor the reaction by TLC, add 10mL water, extract with ethyl acetate (10mL×3), combine the organic phases, dry with anhydrous sodium sulfate, and filter. Concentrate under reduced pressure and separate by column chromatography (V petroleum ether:V ethyl acetate=3:1) to obtain 137.7 mg of gray solid, which is to obtain the target compound with a yield of 93%

References:

CN106800493,2020,B Location in patent:Paragraph 0165-0168

118-48-9 Synthesis