2-(biphenyl-4-yl)acetyl chloride synthesis
- Product Name:2-(biphenyl-4-yl)acetyl chloride
- CAS Number:39889-69-5
- Molecular formula:C14H11ClO
- Molecular Weight:230.69
5728-52-9
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39889-69-5
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Yield:39889-69-5 100%
Reaction Conditions:
with thionyl chloride in benzene at 78 - 80; for 2.5 h;
Steps:
Synthesis of N-substituted 4-biphenyl acid amide from 4-biphenyl acetic acid
4-Biphenyl acetic acid (1 g) dissolved in dry benzene (25 mL), added thionyl chloride (1 mL) dropwise along with constant stirring in a round bottom flask of 50 mL. then refluxed the reaction mixture for 2.5 h on water bath at 78-80 °C. The recovered benzene and thionyl chloride from reaction mixture through distillation traces of solvent through vacuum pump. 4-Biphenyl acetyl chloride (1) obtained as a viscous-oil (1.085 g, 100 % yield).
References:
Khullar, Anju [Asian Journal of Chemistry,2019,vol. 31,# 3,p. 510 - 514]
5728-52-9
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79-37-8
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39889-69-5
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92-92-2
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39889-69-5
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14002-51-8
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39889-69-5
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