2-CYANO-3-(4-PYRIDINYL)ACRYLAMIDE synthesis

Yield:40029-37-6 35%

Reaction Conditions:

with 1-methyl-piperazine in methanol at 20; for 20 h;Aldol condensation;

Steps:

4.2.1. General procedure for the preparation of compounds 1, 5-15, 18-21, 23-33, 35-44, 46-54, 61, 62, 65, 67-69, 72-75, 92

General procedure: A solution of arylaldehyde (1 equiv), 2-cyanoacetamide or derivative (1.0-1.5 equiv) and N-methylpiperazine (0.05-1.05 equiv) in methanol (2-10 ml) was stirred at room temperature overnight. After addition of an equivalent volume of water/methanol (1:1) or 1 N HCl/methanol (1:1) for acidic products, the precipitate was collected by filtration and washed with water/methanol (1:1). If precipitation did not occur, the mixture was evaporated and the residue was purified by flash chromatography.

References:

Nitsche, Christoph;Steuer, Christian;Klein, Christian D. [Bioorganic and Medicinal Chemistry,2011,vol. 19,# 24,p. 7318 - 7337] Location in patent:experimental part