2-Ethyl-4-methyl-1H-imidazole-1-propanenitrile synthesis

Yield:23996-25-0 87%

Reaction Conditions:

with C₂₂H₄₈N₄⁽⁴⁺⁾*4HO^(1-) in neat (no solvent) at 20; for 1.16667 h;Michael Addition;

Steps:

General Procedure for synthesis of Products (3a-3f and 4a-4f) using [n-butyl Urotropinium]OH as catalyst (Catalyst B)
General procedure: α,β-unsaturated compound (4.8 mmol) was added dropwise to a well stirred mixture of N-heterocycle substrate (4.0 mmol) in [n-butyl urotropinium]OH (0.108 g, 0.25 mmol) and the reaction mixture was stirred for required time until completion of reaction (TLC). The product was then directly distilled out from the reaction mixture to provide pure Michael adducts (3a-3f and 4a-4f) in high yields.

References:

Kumar, Sitanshu;Kaur, Amanpreet;Singh, Vasundhara [Synthetic Communications,2019,vol. 49,# 2,p. 193 - 201]

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