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2-Ethylcrotonic acid synthesis

8synthesis methods
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Yield:71.429 % de

Reaction Conditions:

with 6-(quinolin-2-yl)pyridin-2(1H)-one;sodium acetate;palladium diacetate;lithium carbonate;silver carbonate in 1,4-dioxane;tert-Amyl alcohol at 100; for 16 h;Inert atmosphere;Overall yield = 51 percent;

References:

Wang, Zhen;Hu, Liang;Chekshin, Nikita;Zhuang, Zhe;Qian, Shaoqun;Qiao, Jennifer X.;Yu, Jin-Quan [Science,2021,vol. 374,# 6572,p. 1281 - 1285]