3,6-Dichloro-2-methoxybenzyl alcohol synthesis
- Product Name:3,6-Dichloro-2-methoxybenzyl alcohol
- CAS Number:4849-12-1
- Molecular formula:C8H8Cl2O2
- Molecular Weight:207.05
1918-00-9
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$18.00/1g
4849-12-1
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$720.71/5g
Yield:4849-12-1 92%
Reaction Conditions:
with borane-THF in tetrahydrofuran at 0 - 80;
Steps:
168 Intermediate 168a: (3,6-dichloro-2-met oxyphenyl)meth.anol
To a mixture of 3,6-dicliloro-2-raethoxybenzoic acid (1.0 g, 4.52 mmol. 1.00 equiv) in THF (6 mL) at 0 °C was added bora e-ietraliydrofuraii complex solution (1M, 9mL, 9.0 mrnol, 2.00 equiv) dropwise. The mixture was stirred at 80 °C overnight. The mixture was cooled to room temperature, quenched with 2N HCI, and extracted with ethyl acetate. The organic layer was washed with 2N HCI (Ix). 0 (Ix), and brine (ix), dried, and concentrated to give 0.866 g (92%) of (3,6-dk oro-2-methoxyphenyl)methanol as a white solid.
References:
WO2013/96771,2013,A1 Location in patent:Page/Page column 226
