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3-ACETYLAMINO-1-ADAMANTANE ACETIC ACID synthesis

1synthesis methods
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Yield:75667-93-5 68%

Reaction Conditions:

Stage #1: (adamant-1-yl)-acetic acidwith sulfuric acid;nitric acid at 0; for 2 h;
Stage #2: acetonitrile at 0; for 4 h;

References:

Cianfanelli, Marco;Olivo, Giorgio;Milan, Michela;Klein Gebbink, Robertus J. M.;Ribas, Xavi;Bietti, Massimo;Costas, Miquel [Journal of the American Chemical Society,2020,vol. 142,# 3,p. 1584 - 1593] Location in patent:supporting information