3-Nitro-5-(trifluoromethyl)phenol synthesis
- Product Name:3-Nitro-5-(trifluoromethyl)phenol
- CAS Number:349-57-5
- Molecular formula:C7H4F3NO3
- Molecular Weight:207.11
328-79-0
109 suppliers
$15.00/1g
349-57-5
104 suppliers
$29.00/1 g
Yield: 96%
Reaction Conditions:
with hydrogen bromide;acetic acid in waterHeating / reflux;
Steps:
3.1
A solution of 3-nitro-5-(trifluoromethyl)phenyl ether (20.0 g, 0.090 mol) in HBr (74.7 mL, 1.38 mmol) and HOAc (279.8 mL, 4.92 mol) was heated at reflux until reaction was judged to be complete by LCMS. The reaction was concentrated to tan solid to yield the desired product (18.7 g, 96% yield). LCMS: (FA) ES- 206.2 (M-1).
References:
Millennium Pharmaceuticals, Inc. US2006/160803, 2006, A1 Location in patent:Page/Page column 138
401-99-0
240 suppliers
$19.00/25 g
349-57-5
104 suppliers
$29.00/1 g
133532-73-7
4 suppliers
inquiry
133532-73-7
4 suppliers
inquiry
349-57-5
104 suppliers
$29.00/1 g
393-75-9
277 suppliers
$10.00/5g
349-57-5
104 suppliers
$29.00/1 g
454-73-9
102 suppliers
$8.00/250mg
349-57-5
104 suppliers
$29.00/1 g