ChemicalBook CAS DataBase List 4-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BUTANOIC ACID

4-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BUTANOIC ACID synthesis

12synthesis methods

Product Name:4-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BUTANOIC ACID
CAS Number:3130-75-4
Molecular formula:C12H11NO4
Molecular Weight:233.22

627-00-9 Synthesis

627-00-9
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1074-82-4
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4-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BUTANOIC ACID

3130-75-4
149 suppliers
$24.00/100mg

Yield: 80%

Reaction Conditions:

in water;N,N-dimethyl-formamide

Steps:

14.m (m)
(m) Preparation of gamma-phthalimidobutyric acid 3 g of 4-chlorobutyric acid is reacted with 4.5 g (molar ratio 1/1) of potassium phthalimide in 60 ml of DMF with stirring and at room temperature. The reaction mixture is then treated after 2 hours by adding water and filtering the precipitate so formed. After crystallization from ethanol, 4.6 g of phthalimidobutyric acid is obtained with 80% yield.

References:

Instituto Chimico Internazionale Dr. Giuseppe Rende S.r.l. US5010204, 1991, A

85-44-9 Synthesis