ChemicalBook CAS DataBase List 4-(1H-IMIDAZOL-1-YL)BENZOIC ACID

4-(1H-IMIDAZOL-1-YL)BENZOIC ACID synthesis

9synthesis methods

Product Name:4-(1H-IMIDAZOL-1-YL)BENZOIC ACID
CAS Number:17616-04-5
Molecular formula:C10H8N2O2
Molecular Weight:188.18

288-32-4 Synthesis

288-32-4
972 suppliers
$5.00/25g

619-58-9
423 suppliers
$8.00/5g

17616-04-5
127 suppliers
$20.00/250mg

Yield:17616-04-5 93 %Chromat.

Reaction Conditions:

with C₁₆H₁₂ClN₃OPdS;potassium hydroxide in dimethyl sulfoxide at 110; for 10 h;

Steps:

2.3. Catalytic arylation of nitrogen-containing heterocycles with aryl halides

General procedure: Arylhalide (1.0 mM), nitrogen-containing heterocycle (1.2 mM), KOH (2 mM), and the catalyst (0.75 M%) were stirred in dimethyl sulfoxide (DMSO) (4 mL) at 110 °C for 10 h. After completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate (10 mL) and filtered. The filtrate was concentrated and the residue was purified by column chromatography on silica gel using hexane/ethyl acetate(70 : 30) as eluent to afford the desired product. The products have been characterized by 1H NMR spectroscopy.

References:

Anitha, Panneerselvam;Manikandan, Rajendran;Viswanathamurthi, Periasamy [Journal of Coordination Chemistry,2015,vol. 68,# 19,p. 3537 - 3550]