4-(1H-PYRAZOL-1-YL)BENZOIC ACID synthesis
- Product Name:4-(1H-PYRAZOL-1-YL)BENZOIC ACID
- CAS Number:16209-00-0
- Molecular formula:C10H8N2O2
- Molecular Weight:188.18
25699-83-6
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$7.00/250mg
16209-00-0
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$20.00/500mg
Yield:16209-00-0 65%
Reaction Conditions:
with water in ethanol at 105; for 16 h;
Steps:
1 Preparation of 4-(1H-pyrazol-1-yl)biphenylcarboxamide compounds containing diphenyl ether group:
4-(1H-pyrazol-1-yl)benzonitrile (0.338 g, 1.0 mmol) was dissolved in 25 mL (ethanol/water,volume ratio, 1:1), the temperature was raised to 105°C under stirring for 16h, the reaction solution was poured into water,Ethyl acetate (30 mL) was extracted, the aqueous phase was acidified to pH=5 at 6.0 mol/L, and a solid was precipitated.Suction filtration and drying to obtain 4-(1H-pyrazol-1-yl)benzoic acid as a white solid with a yield of 65%.
References:
CN113880765,2022,A Location in patent:Paragraph 0032-0034
1194-02-1
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$6.00/10g
16209-00-0
153 suppliers
$20.00/500mg
403-33-8
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$13.43/1gm:
16209-00-0
153 suppliers
$20.00/500mg