ChemicalBook CAS DataBase List 4-CHLORO-6-HYDROXYQUINAZOLINE

4-CHLORO-6-HYDROXYQUINAZOLINE synthesis

6synthesis methods

Product Name:4-CHLORO-6-HYDROXYQUINAZOLINE
CAS Number:848438-50-6
Molecular formula:C8H5ClN2O
Molecular Weight:180.59

179246-11-8 Synthesis

179246-11-8
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848438-50-6
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Yield:848438-50-6 95%

Reaction Conditions:

with ammonia in methanol at 20; for 3 h;Inert atmosphere;

Steps:

The fourth step: the synthesis of 4-chloroquinazolin-6-ol

Dissolve 4-chloroquinazolin-6-yl acetate (700 mg, 3.144 mmol) in methanol (5 mL), add 7N ammonia methanol solution (15 mL), stir at room temperature for 3 hours, add methyl tert-butyl ether, and precipitate The product was precipitated, filtered, and the filter cake was washed with an appropriate amount of methyl tert-butyl ether, and dried to obtain 4-chloroquinazolin-6-ol (600 mg, yield: 95%).

References:

WO2022/105908,2022,A1 Location in patent:Page/Page column 24; 38