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5-bromo-N4-ethylpyridine-3,4-diamine synthesis

2synthesis methods
-

Yield:607371-03-9 93%

Reaction Conditions:

with iron;acetic acid at 75; for 1 h;Inert atmosphere;

References:

Heerding, Dirk A.;Rhodes, Nelson;Leber, Jack D.;Clark, Tammy J.;Keenan, Richard M.;Lafrance, Louis V.;Li, Mei;Safonov, Igor G.;Takata, Dennis T.;Venslavsky, Joseph W.;Yamashita, Dennis S.;Choudhry, Anthony E.;Copeland, Robert A.;Lai, Zhihong;Schaber, Michael D.;Tummino, Peter J.;Strum, Susan L.;Wood, Edgar R.;Duckett, Derek R.;Eberwein, Derek;Knick, Victoria B.;Lansing, Timothy J.;McConnell, Randy T.;Zhang, ShuYun;Minthorn, Elisabeth A.;Concha, Nestor O.;Warren, Gregory L.;Kumar, Rakesh [Journal of Medicinal Chemistry,2008,vol. 51,# 18,p. 5663 - 5679] Location in patent:experimental part