5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid synthesis
- Product Name:5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
- CAS Number:253870-02-9
- Molecular formula:C8H9NO3
- Molecular Weight:167.16
2199-59-9
232 suppliers
$8.00/250mg
253870-02-9
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$6.00/1g
Yield:253870-02-9 93%
Reaction Conditions:
with potassium hydroxide in methanol;water
Steps:
1.2 Step 2
Step 2 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester (2 g, 10 mmol) was added to a solution of potassium hydroxide (3 g, 53 mmol) dissolved in methanol (3 mL) and water (10 mL). The mixture was refluxed for 3 hours, cooled to room temperature and acidified with 6 N hydrochloric acid to pH 3. The solid was collected by filtration, washed with water and dried in a vacuum oven overnight to give 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (1.6 g, 93%). 1H NMR (300 MHz, DMSO-d6) δ 12.09 (s, br, 2H, NH & COOH), 9.59 (s, 1H, CHO), 2.44 (s, 3H, CH3), 2.40 (s, 3H, CH3).
References:
SUGEN, INC. US2003/92917, 2003, A1
2199-59-9
232 suppliers
$8.00/250mg
253870-02-9
360 suppliers
$6.00/1g
37059-18-0
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253870-02-9
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86770-31-2
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253870-02-9
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2199-51-1
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$7.00/250mg
253870-02-9
360 suppliers
$6.00/1g