5-Hydroxyisophthalic acid synthesis
- Product Name:5-Hydroxyisophthalic acid
- CAS Number:618-83-7
- Molecular formula:C8H6O5
- Molecular Weight:182.13
13036-02-7
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618-83-7
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Yield:618-83-7 58%
Reaction Conditions:
Stage #1: Dimethyl 5-hydroxyisophthalatewith water;lithium hydroxide in tetrahydrofuran at 40;
Stage #2: with hydrogenchloride in water; pH=~ 2;
Steps:
193.1
To dimethyl 5-hydroxyisophthalate (4 0 g, 19 03 mmol, 1 00 equiv) in THF (10 mL) was added lithium hydroxide (20 mL, 2M in water) and the resulting solution was stirred overnight at 4O0C The mixture concentrated under vacuum to remove the organic solvents and then the pH of the solution was adjusted to ~2 with 6N hydrochloric acid The resulting solids were collected by filtration and d?ed in a vacuum oven to afford 2 O g (58%) of 5- hydroxyisophthahc acid as a white solid.
References:
WO2010/78449,2010,A2 Location in patent:Page/Page column 317
23351-91-9
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618-83-7
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121-91-5
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618-83-7
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618-83-7
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855397-05-6
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618-83-7
294 suppliers
$9.00/10g