2-Methyl-1[4-(trifluoromethoxy)phenyl] propan-1-one synthesis
- Product Name:2-Methyl-1[4-(trifluoromethoxy)phenyl] propan-1-one
- CAS Number:56425-84-4
- Molecular formula:C11H11F3O2
- Molecular Weight:232.2
332-25-2
181 suppliers
$7.00/5g
920-39-8
222 suppliers
$68.00/100ml
56425-84-4
99 suppliers
$29.00/100mg
Yield:-
Reaction Conditions:
with mercury in diethyl ether;toluene
Steps:
4 Isopropyl 4-trifluoromethoxyphenyl ketone
Preparation 4 Isopropyl 4-trifluoromethoxyphenyl ketone A 10 g. portion of 4-trifluoromethoxybenzonitrile was added to 50 ml. of toluene, and the mixture was stirred at 20° C. while 24 ml. of 2.85-molar isopropyl magnesium bromide solution in diethyl ether was added dropwise over 5 minutes. The mixture was then heated to 55° C. for 4 hours. The mixture was then cooled to ambient temperature, and was poured over ice-hydrochloric acid. The aqueous mixture was then distilled until the temperature rose to 90° C., and was then stirred under reflux for 30 minutes and cooled. The layers were separated, and the aqueous layer was extracted 3 times with 25 ml. portions of dichloromethane. The combined organic layers were dried over sodium sulfate, and the solvent was removed. The residue was then distilled, and the product was collected at 22 mm. mercury and 115°-117° C. The yield was 10.9 g. of the desired product. The product of Preparation 4 is used to prepare α-isopropyl-α-(4-trifluoromethoxyphenyl)-5-pyrimidinemethanol as taught in U.S. Pat. No. 4,110,099.
References:
Eli Lilly and Company US4318866, 1982, A
456-55-3
301 suppliers
$6.00/10g
79-30-1
360 suppliers
$10.00/10g
56425-84-4
99 suppliers
$29.00/100mg